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5-MeO-DMT is a psychedelic alkaloid of the tryptamine class, four to six times more powerful than its better-known relative, N, N-dimethyltryptamine. Interestingly, 5-MeO-DMT actually contains N, N-DMT, and is simply a methoxylated N, N-DMT molecule.
5-MeO-DMT is most commonly found in the milky white venom of the Sonoran Desert Toad (Bufo alvarius/Incilius alvarius), which is native to the southwestern United States and northwestern Mexico. Venom harvesting has put pressure on the population of this ecologically sensitive species, and the species is currently listed as imperiled or locally extinct in several states. 5-MeO-DMT can also be synthetically produced, and out of respect for the endangered Toad species, the 5-MeO-DMT that we offer is synthesized.
5-Meo-DMT has a long history of ceremonial use among indigenous Amazonians, and the substance has also shown great promise in the treatment of numerous medical conditions. In fact, a single inhalation of the substance has been shown to greatly improve general well-being and mindfulness as well as reduce the symptoms of psychological disorders.
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While research into 5-MeO-DMT is limited, a few studies have supported the anecdotal evidence. In a recent preliminary study, 42 participants who took 5-MeO-DMT reported high levels of life satisfaction and mindfulness as well as lower levels of depression and anxiety. These positive effects persisted for up to four weeks (when a follow-up assessment was completed). These results support the findings of a survey of 362 people who had taken 5-MeO-DMT. After using the psychedelic, 80% of respondents reported improvements in anxiety and depression.
5-MeO-DMT has seen a drastic rise in popularity over the past few years as anecdotal reports of its potential as a healing agent have come to light, and as it has been a featured topic in productions including the Joe Rogan Experience, Mike Tyson podcast, and multiple Netflix specials.
The 5-MeO-DMT Experience
Vaporizing or smoking 5-MeO-DMT powder is the most common route of administration. The effects are usually felt within the first 30 seconds after consumption, peaking from 1-15 minutes and lasting for up to half an hour. When taken orally, effects are nonexistent, leading some chemists (most notably Alexander Shulgin) to assume that the act of smoking/vaporizing changes the molecular structure of the compound, making it psychoactive.
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Mixing 5MEO DMT into a solution for use with in vaporizer cartridge is a newer form of ingestion with significant benefits over smoking freebase 5MEO DMT powder – namely the ease of consumption. Because the intensity of 5MEO DMT depends on the dose, vaping it can cause hallucinations that are as or more intense than consuming it in more traditional ways, as long as proper dosage is received within a short period of time (this sometimes takes several “pulls” or “hits” on a vaporizer).
- Low doses (2-5mg) of 5MEO DMT primarily affect physical and emotional states with few to no perceptual hallucinations. For most people this is between 2-5mg of 5-MeO-DMT
- High doses (10-15mg) of 5MEO DMT will result in fast-acting effects that come on strong, often with a loss of physical coordination and control. Users experience bright colors, moving environments, or recursive patterns, and perhaps even “environmental orbism” at higher doses. However, visual effects are limited. Unlike N,N-DMT, 5-MeO-DMT isn’t known for its visionary properties. The experience is more often described as a “perspective shift” characterized by physical, emotional, and conceptual effects. It’s also common to experience an overwhelming sense of oneness with the universe, or a sense of being outside of time and space while simultaneously experiencing the totality of both. Ego death is also typical of the 5-MeO-DMT experience. Other effects include auditory hallucinations, and time distortion
Like the other tryptamines, 5-MeO-DMT has the same basic structure as N, N-DMT, but has a methoxy group in the R5 position. It works primarily as a serotonin (5-HT) receptor agonist, with a particular binding affinity to the 5-HT1A receptor subtype. It also binds to 5-HT2A and trace amine receptors, possibly mediating hallucinogenic effects via the latter. Reuptake inhibition of neurotransmitters such as noradrenaline and dopamine are also thought to be involved in 5-MeO-DMT’s function.
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5-MeO-DMT has been described by many as the most potent psychedelic on the face of the planet. It is about 4-6 times more potent than its relative, N,N-dimethyltryptamine. It is commonly found in Sonoran Desert Toad/Colorado River Toad. 5-MeO-DMT is known as “the God molecule” because it often elicits full blown mystical or spiritual experiences, wherein the subject alleges a communion with god or a divine consciousness. It catapults the user into vivid visual hallucination, completely unhinges any sense of time, and can reveal deeply meaningful/powerful insights about the very nature of reality itself.
While 5-MeO-DMT is the most potent psychedelic out there, it’s also one of the fastest acting. Smoking or vaporizing 5-MeO-DMT will elicit an experience between 15-20 minutes in duration, however during this experience you may completely forget that time exists at all.